1.
J Org Chem
; 88(14): 9987-10001, 2023 Jul 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37406306
RESUMO
A facile one-pot metal-free, base-mediated formal [3 + 2] and [4 + 2] dearomative ipso-cycloaddition of para-quinone methides (p-QMs) with halo alcohols has been designed for the efficient construction of 2-oxa-spirocyclohexadienones in excellent yield under mild reaction conditions. The commercial availability of the bases, reagents, and convenient reaction procedure makes it an attractive method for ipso-cyclization.